ABSTRACT
ABSTRACT We report a case of a young Caucasian female presenting with sudden decrease of vision in the left eye, metamorphopsia, and nasal scotoma. Past medical history revealed a diagnosis of myasthenia gravis, which was currently treated with azathioprine, pyridostigmine, and prednisone. Ophthalmological examination showed fundus with clear vitreous and yellow-white lesions that were isolated and perimacular in the right eye, multiple and confluent in the macula, and punctate in periphery in the left eye. Laboratory workup ruled out the presence of infectious and inflammatory diseases. Fundus autofluorescence disclosed hypoautoflurescence with hyperfluorescent margins corresponding to the lesions observed in both eyes and the angiogram revealed hyperfluorescence since early phases without late leakage. Spectral-domain optical coherence tomography showed areas of intermittent retinal pigment epithelium elevations and disruption of the ellipsoid zone. She was diagnosed with punctate inner choroidopathy and then treated with an increased dose of daily prednisone, which resulted in progressive improvement of her visual acuity and anatomical status.(AU)
RESUMO Relato de caso de mulher jovem, caucasiana, com súbita diminuição de acuidade visual de olho esquerdo, metamorfopsia e escotoma nasal. Apresentava diagnóstico de Miastenia gravis, em tratamento com Azatioprina, Piridostigmina e Prednisona. Fundo de olho demonstrava vítreo límpido e lesões amarelo-esbranquiçadas, perimaculares e isoladas em olho direito, múltiplas e confluentes em mácula e pontilhadas em periferia no olho esquerdo. Exames laboratoriais descartaram doenças infecciosas e inflamatórias. Auto-fluorescência revelou lesões hipoautofluorescentes com margens hiperfluorescentes correspondentes às observadas em ambos os olhos, enquanto angiofluoresceinografia mostrou hiperfluorescência desde as fases iniciais sem vazamento tardio. Tomografia de coerência óptica de domínio espectral revelou áreas de elevações intermitentes do epitélio pigmentar da retina e interrupção da zona elipsóide correspondente. Definiu-se como diagnóstico a coroidopatia interna ponteada, sendo instituído aumento na dose diária de Prednisona, com melhoria progressiva da acuidade visual e do aspecto de fundo de olho da paciente.(AU)
Subject(s)
Humans , Female , Adult , Visual Acuity , Choroiditis/physiopathology , Fluorescein Angiography/instrumentation , Tomography, Optical Coherence/instrumentation , Multimodal Imaging/instrumentation , Optical Imaging/instrumentationABSTRACT
RESUMO Este trabalho visou evidenciar a importância da detecção precoce da coroidite interna punctata e destacar sua fisiopatologia inflamatória e possíveis diagnósticos diferenciais dentro das white dot syndromes. O destaque foi dado principalmente à coroidite multifocal e à panuveíte, ao se demonstrar sua epidemiologia peculiar em mulheres jovens, caracterizar sua apresentação clínica típica na fundoscopia e explorar as vantagens e as desvantagens de realizar os exames complementares que fazem parte da análise multimodal útil para o diagnóstico (especialmente a angiografia fluoresceínica, a tomografia de coerência óptica e a indocianina verde). Descreve-se o caso de uma mulher de 28 anos diagnosticada com coroidite interna punctata com membrana neovascular coroidal em olho direito. O tratamento foi realizado com injeção intravítrea de aflibercepte e corticoterapia sistêmica 1mg/kg ao dia. Este relato é importante por permitir debater o manejo da coroidite interna punctata durante a gestação e a decisão de realizar o tratamento mediante uma diversidade de opções terapêuticas.
ABSTRACT This work aimed to demonstrate the importance of early detection of punctate inner choroidopathy, highlighting the pathophysiology of inflammation and the differential diagnoses among white dot syndromes. Special attention was given to multifocal choroiditis and panuveitis, by demonstrating the peculiar epidemiology in young women, characterizing the typical clinical presentation in ophthalmoscopy, and exploring the advantages and disadvantages of performing the complementary examinations, which are part of the multimodal analysis useful for diagnosis (particularly fluorescein angiography, optical coherence tomography, and indocyanine green). We report the case of a 28-year-old female, diagnosed as punctate inner choroidopathy with choroidal [N.T. no título aparece subretinal = subrretiniana] neovascular membrane in the right eye. She was treated with intravitreal injection of aflibercept and systemic corticosteroid 1 mg/kg/day. This case report is important for addressing the management of punctate inner choroidopathy during pregnancy, and the decision to carry out treatment considering diverse therapeutic options.
Subject(s)
Humans , Female , Adult , Choroiditis/complications , Choroiditis/diagnosis , Choroiditis/physiopathology , Choroidal Neovascularization/etiology , Angiogenesis Inhibitors/therapeutic use , Intravitreal Injections/methods , Fluorescein Angiography/methods , Tomography, Optical Coherence/methodsABSTRACT
A 28-year-old, healthy female, who had a recent repeated history of miscarriage, presented with bilateral choroidal neovascular membranes (CNVM), for which she received photodynamic therapy with three doses of lucentis, at intervals of one month each, to which she responded. After five months, the patient again presented with complaints of diminution of vision since 15 days. She had a history of miscarriage two days before presenting to our clinic. CNVM was scarred at this time and the fundus picture showed multiple small punctate spots around the fovea at the level of the choroid, which showed early hyperfluroscence on fundus fluorescein angiography, suggestive of punctate inner choroidopathy. She was advised systemic steroids, to which she responded dramatically.
Subject(s)
Adult , Choroid Diseases/complications , Choroid Diseases/diagnosis , Choroid Diseases/drug therapy , Choroidal Neovascularization/complications , Choroidal Neovascularization/pathology , Choroiditis/complications , Choroiditis/physiopathology , Female , Fluorescein Angiography , Fundus Oculi , Humans , Pregnancy , Pregnancy Complications , Pregnancy Trimester, First , Steroids/therapeutic use , Tomography, Optical CoherenceABSTRACT
Presentamos la evolución clínica de una paciente de 11 años de edad con panuveítis bilateral recurrente, caracterizada por la presencia de múltiples focos de coroiditis, atrofia peripapilar y fibrosis subretiniana. Se hacen consideraciones acerca del diagnóstico diferencial y tratamiento.
Subject(s)
Adolescent , Humans , Female , Steroids/therapeutic use , Fibrosis/prevention & control , Panuveitis/diagnosis , Choroiditis/physiopathology , Eye Diseases/diagnosis , Histoplasmosis/physiopathology , Electrooculography/methods , Electroretinography/methods , Visual Perception/physiologyABSTRACT
Desde o início dos anos 80 tem-se observado um aumento da associaçäo da infecçäo pelo Mycobacterium tuberculosis e o paciente infectado pelo HIV ou com AIDS. Quatro pacientes portadores de AIDS, tuberculose e manifestaçöes oculares säo descritos pelos autores. Dois pacientes eram portadores de tuberculose miliar, um com tuberculose pulmonar com padräo radiológico atípico e um paciente com tuberculose ganglionar. Até a presente data, este é o primeiro relato de presumível coroidite tuberculosa em pacientes com AIDS, apesar da alta prevalência da tuberculose no Brasil
Subject(s)
Humans , Male , Adult , Choroiditis/physiopathology , Eye Manifestations , HIV Infections/complications , Mycobacterium tuberculosis/immunology , Tuberculosis, Miliary/physiopathology , Tuberculosis, Pulmonary/physiopathology , Tuberculosis/physiopathology , Choroiditis/etiologyABSTRACT
Os autores apresentam um caso de coroidopatia geográfica típica, abordando principalmente as suas características clínicas e sua história natural